Chemical name LD50 oral LD50 dermal LC50 inhalation Guaifenesin 1510 mg/kg Rat Not Available Not Available Codeine Phosphate 85 mg/kg Rat Not Available Not Available Edetate Disodium >2000 mg/kg Rat Not Available Not Available Menthol 3300 mg/kg Rat 5001 mg/kg Rabbit Not Available Sodium Citrate Not Available Not Available Not Available. The LD-50 is apparently reported at 1510 mg/kg (per rat studies), so you'd have to take a fuckton to actually die. an LD50 value of 1510 mg/kg (rat, oral) has been reported for guaifenesin. I don't advise it at all but when I first got into dexxing I took like well over 20 grams with muccinex DM The LD50 of guaifenesin for rats is 1510 mg/kg. So, for an average 70kg human, a dose of 105 grams would be lethal to 50% of the population
Common guaifenesin side effects may include: dizziness, headache; drowsiness; rash; or. nausea, vomiting, stomach upset. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Guaifenesin side effects (more detail Guaifenesin LD50 oral rat 300 - 2000 mg/kg . Guaifenesin Safety Data Sheet Safety Data Sheet in accordance with regulation (EC) No 1907/2006, as amended. 22/05/2017 EN (English) 4/5 Skin corrosion/irritation : Not classified (Lack of data
. to OSHA HCS Printing date 05/03/2021 Revision date 05/03/2021 Trade name:Guaifenesin (Contd. from page 6) 53.0 · Transport hazard class(es) · DOT, ADN, IMDG, IATA · Class not regulated · Packing group · DOT, IMDG, IATA not regulated · Environmental hazards: Not applicable. · Special precautions for user Not applicable. · Transport in bulk according to. Moreover, guaifenesin is excreted in breast milk in small quantities 7. Subsequently, caution should be exercised by balancing the potential benefit of treatment against any possible risks 7. Additionally, an LD 50 value of 1510 mg/kg (rat, oral) has been reported for guaifenesin MSDS. Pathways Not Available Pharmacogenomic Effects/ADR
Guaifenesin (93-14-1) Oral LD50 Rat: 1510 mg/kg Paracetamol (UK) or Acetaminophen (USA) (103-90-2) Oral Rat LD50: 2404 mg/kg IPR-Rat LD50: 1205 mg/kg IPR-Mouse LD50: 367 mg/kg Propylene glycol (57-55-6) Oral LD50 Rat: 20000 mg/kg; Dermal LD50 Rabbit:20800 mg/kg Sorbitol (50-70-4) Oral LD50 Rat (IV) 29,600 mg/kg Oral LD50 mouse: 17,800 mg/k Guaifenesin is a centrally acting muscle-relaxant that is used as a part of many anesthetic protocols in the horse. Its mechanism of action is not precisely known but the relaxation of skeletal muscles, mild analgesic and mild sedative properties allows for lower doses of other sedatives and anesthetic agents
Guaifenesin (93-14-1) Oral LD50 Rat: 1510 mg/kg Paracetamol (UK) or Acetaminophen (USA) (103-90-2) Oral Rat LD50: 2404 mg/kg IPR-Rat LD50: 1205 mg/kg IPR-Mouse LD50: 367 mg/kg Phenylephrine Hydrochloride (61-76-1) LD50 Oral Mouse: 120 mg/kg LD50 Oral Rat: 350 mg/kg Diphenhydramine Hydrochloride (147-24-0) LD50 Oral Mouse: 164mg/kg LD50 Oral Rat. Chemsrc provides Guaifenesin(CAS#:93-14-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Guaifenesin are included as well Guaifenesin Safety Profile. Safety Information about Guaifenesin (CAS NO.93-14-1): Hazard Codes: Xn. Risk Statements: 22-36/37/38. R22: Harmful if swallowed. R36/37/38: Irritating to eyes, respiratory system and skin. Safety Statements: 26-36. S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
Guaifenesin. undefined. Synonyms: 3-( o -Methoxyphenoxy)-1,2-propanediol, Guaifenesin, Guaiacol glyceryl ether, Glycerol guaiacolate. CAS 93-14-1. Molecular Weight 198.22. Browse Guaifenesin and related products at MilliporeSigma The Koc of guaifenesin is estimated as 140(SRC), using a log Kow of 1.39(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that guaifenesin is expected to have high mobility in soil. 12.5 Other adverse effects. no data available. 13. Disposal considerations 13.1 Disposal methods.
Guaifenesin United States Pharmacopeia (USP) Reference Standard; CAS Number: 93-14-1; Synonyms: 3-(o-Methoxyphenoxy)-1,2-propanediol,Guaifenesin,Guaiacol glyceryl ether,Glycerol guaiacolate; find USP-1301007 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldric . However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use.
, best-sellers & recommendations from our reader Guaifenesin is used for dry, nonproductive cough when there is the presence of tenacious mucus and/or mucus plugs. The results of a few studies have favored active treatment with guaifenesin over placebo in treating productive cough due to upper respiratory illness (URI) UNITED STATES PHARMACOPEIAL CONVENTION INC -- GUAIFENESIN -- 6505-01-147-9537 ===== Product Identification ===== Product ID:GUAIFENESIN MSDS Date:07/18/1986 FSC:6505 NIIN:01-147-9537 MSDS Number: BXNZT === Responsible Party === Company Name:UNITED STATES PHARMACOPEIAL CONVENTION INC Address:12601 TWINBROOK PKWY City:ROCKVILLE State:MD ZIP:20852-1717 Country:US Info Phone Num:301-881-0666. Guaifenesin is a common medication used to treat chest congestion. This lesson discusses risks associated with its usage including possible drug interactions, known side effects, and potential for. Lethal Dose Table Lethal dose (LD 50) is the amount of an ingested substance that kills 50 percent of a test sample. It is expressed in mg/kg, or milligrams of substance per kilogram of body weight. Common name Toxin Lethal doses Description Toxic response Aspirin Acetyl- salicylic acid C 9 H 8 O 4 LD 50 200 mg/kg (rat, oral) Odorless white crysta
LD50 Rat > 5000 mg/kg/day Read across from similar polymers LIGHT MINERAL OIL (CAS 8042-47-5) Oral Acute LD50 Rat > 2000 mg/kg L-MENTHOL (CAS 2216-51-5) Oral Acute LD50 Rat 3300 mg/kg 5 / 9 Material name: DENTURE ADHESIVE CREAM 133044 Version #: 12 Revision date: 02-11-2016 Issue date: 02-13-2014 SDS U Guaifenesin overdose is not really fatal but extra care should be exerted to ensure that the person can recover and revive of the overdose. They should be aware of the side effects, allergic reaction and potential adverse effect of the indicated drugs. Awareness and adequate knowledge is the key in order to spot and differentiate it from overdose . Like most other drugs, I'd eventually developed a great tolerance Guanfacine. Not to be confused with Guanine, Guanosine, Guanidine, Guaifenesin, or Clonidine. Guanfacine, sold under the brand name Tenex among others, is an oral medication used to treat attention deficit hyperactivity disorder (ADHD) and high blood pressure. It is not considered a first-line treatment for either indication Guaifenesin sc-205710 Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Guaifenesin STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. copy of the MSDS should be provided. Further action will be the responsibility of the.
It is a common ingredient in many over-the-counter cough/cold medications. Guaifenesin is also used in the experimental guaifenesin protocol in the treatment of fibromyalgia. It was first approved by the Food and Drug Administration (FDA) in 1952. Guaifenesin works by drawing water into the bronchi Guaifenesin. Guaifenesin INN or guaiphenesin (former BAN), also glyceryl guaiacolate, is an expectorant drug sold over the counter and usually taken orally to assist the bringing up (expectoration) of phlegm from the airways in acute respiratory tract infections Stacy Wiegman, PharmD. The maximum daily adult dosage of both regular and extended-release guaifenesin is 2.4 grams. It is generally recommended that adults take between 200 and 400 milligrams (mg.) of regular guaifenesin, every four hours. While it is unlikely that you will overdose on guaifenesin, you can minimize your risk by taking only one. 93-14-1 - HSRJKNPTNIJEKV-UHFFFAOYSA-N - Guaifenesin [USAN:USP:INN:BAN:JAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information
Guaifenesin is an expectorant. It works by thinning and loosening mucus in the airways, clearing congestion, and making breathing easier.If you are self-treating with this medication, it is. Guaifenesin is an accepted expectorant in the OTC monograph (21CFR 341.18 for Cough, Cold, Allergy, Bronchodilator, and Antiasthmatic Drug Products for Over-the Counter Use). Guaifenesin was approved as Mucinex extended release tablets on July 12, 2002 (Reckitt Benckiser, NDA 21282). Chronic toxicity studies with guaifenesin hav Guaifenesin has antitussive effects, it can inhibit the cough-reflex sensitivity in acute viral cough, it is an expectorant commonly by thinning the mucus or phlegm in the lungs. In vivo. Guaifenesin Pharmacokinetics Following Single-Dose Oral Administration in Children Aged 2 to 17 Years
. (May also be spelt guaiphenesin) This leaflet is intended to provide information on the active ingredient guaifenesin, which is contained in many different medicines. The packaging of the medicine you have bought should be read carefully Guaifenesin CasNo.93-14-1 MSDS,Materials Safety Data Sheets etc Guaifenesin Iupac Name：3-(2-methoxyphenoxy)propane-1,2-diol CAS No.：93-14-1 Molecular Weight：198.21576 Introduction: Guaifenesin is an oral expectorant drug.The expectorant action of guaifenesin is mediated by stimulation of the gastrointestinal tract Oral: Rat: LD50: (mg/kg): 145 Dermal: Rabbit LD50: (mg/kg): 290 Inhalation: Rat: LC50: (mg/L/4hr): Not available ACUTE TOXICITY Based on available data, the classification criteria are not met. Causes irritation. SKIN CORROSION/IRRITATION Based on available data, the classification criteria are not met. Causes irritation. SERIOUS EYE DAMAGE/EYE. Guaifenesin: Guaifenesin has a plasma half-life of approximately 1 hour. Guaifenesin is rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite. No unchanged drug could be detected in the urine following administration of oral guaifenesin
Guaifenesin is an expectorant that works by reducing mucus obstruction in the airways, loosening chest congestion , while dextromethorphan is a cough suppressant that works by blocking cough signals from reaching the brain . How much Robitussin DM to give a dog. Never give more than the prescribed dose Guaifenesin: CAS Number: 93-14-1: 1.2 Relevant identified uses of the substance or mixture and uses advised against; Identified uses: For research use only, not for human or veterinary use. 1.3 Details of the supplier of the safety data sheet; Company: Abmole Bioscience Inc. 8300 FM 1960 West, Suite 450 Houston, TX 77070, USA www.abmole.com: 1. Molbase Encyclopedia provides Guaifenesin (93-14-1) basic information, physical and chemical properties, safety information, toxicity, customs data, synthetic routes, maps, MSDS, generation methods and uses, and its upstream and downstream products, find Guaifenesin introduction, on the Molbase Encyclopedia When codeine, a mild opioid narcotic, was moved to Schedule III and required a prescription for purchase, drugs containing dextromethorphan were popularized since the active ingredient was believed to be safer.. Unfortunately, dextromethorphan has been shown to be habit-forming and intoxicating. It is now a drug of abuse that can even cause a life-threatening overdose when a person consumes.
Guaifenesin Centr ally acting muscle relaxant for induction of general anesthesia 25-100 mg/kg Given to effect Heparin Anticoagulant used for adhesion prevention; DIC; prevention of thromboembolic disease Decrease in PCV caused by erythrocyte agglutination 40-60 U/kg IV or SQ q8-12h Concentration varies but 20 000 U (2 mL of 10 00 Lanier BQ, Miller J. Successful long-term, adjunctive use of guaifenesin in a patient with a complex atopic medical history and primary immune deficiency: A case report. Respiratory Medicine Case. Robitussin DM contains 100 mg of guaifenesin and 10 mg of dextromethorphan in each 5 ml of liquid. Robitussin DM Maximum Strength and contains 400 mg of guaifenesin and 20 mg of dextromethorphan in each 10 ml of liquid. Robitussin DM Maximum Strength is available in 4 fluid ounce (120 ml) and 8 fluid ounce (240 ml) bottles
MATERIAL: GUAIFENESIN SYRUP w/DEXTROMETHORPHAN (Non-Alcoholic) MANUFACTURER: PHARMACEUTICAL ASSOCIATES, INC. 201 Delaware Street Greenville, S.C. 29605 EMERGENCY NUMBER: Poison Control Center 1-800-922-1117 ACTIVE INGREDIENTS: Guaifenesin, USP 100 mg Dextromethorphan HBr, USP 10 m Guaifenesin is administered by rapid infusion until the animal begins to sway on its feet. At this stage either ketamine, thiopental or propofol is administered at a bolus dose. The duration of action of these combinations is variable depending on the animal and the other drugs administered Revision: 06/05/2018 Page: 3 of 5 Gabapentin SAFETY DATA SHEET Supersedes Revision: 06/20/2017 6.3 6.1 6.2 Section 6. Accidental Release Measures Contain spill and collect, as appropriate Dextromethorphan is a 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a- (epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough guaifenesin: oral (ld50): acute: 1510 mg/kg (rat). 690 mg/kg (mouse). 2553 mg/kg (rabbit). section 3. hazards identification : potential acute health effects: slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation
Dextromethorphan, guaifenesin, and phenylephrine is a combination medicine used to treat cough, stuffy nose, and chest congestion caused by allergies, the common cold, or the flu Mutagenicity; Dominant lethal assay in rats; Result: Negative. GERM CELL MUTAGENICITY CARCINOGENICITY OSHA MENTHOL (L) is not listed. NTP MENTHOL (L) is not listed. IARC MENTHOL (L) is not evaluated. This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm. Guaifenesin is not an especially toxic medication. Thus, it is unlikely to cause bothersome or serious side effects at normal dosages. Higher dosages, as might be seen in the case of a guaifenesin overdose, might cause vomiting. Keep in mind that guaifenesin cough syrups may contain alcohol and, therefore, may lead to alcohol poisoning in the. The oral LD50 of phenylephrine in rats and mice is 350 mg/kg and 120 mg/kg, respectively.6 Because of low oral bioavailability, the acute oral toxicity is lower for phenylephrine than with other sympathomimetics such as pseudoephedrine, and parenteral administration is more likely to result in marked clinical signs of toxicosis compared with. In 1981, a paper by Gosselin estimated that the lethal dose is between 50 and 500 mg/kg. Doses as high as 15-20 mg/kg are taken by some recreational users. A single case study suggests that the antidote to dextromethorphan overdose is naloxone, administered intravenously
LD50 Oral - rat - 1.944 mg/kg Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals. Germ cell mutagenicity no data available. The LD 50 of pseudoephedrine (single oral dose) has been reported to be 726 mg/kg in the mouse, 2206 mg/kg in the rat and 1177 mg/kg in the rabbit. The toxic and lethal concentrations in human biologic fluids are not known. Urinary excretion increases with acidification and decreases with alkalinization of the urine Safety Data Sheet according to 29CFR1910/1200 and GHS Rev. 3 Effective date : 11.19.2014 Page 2 of 9 Ethanol,95%, 4L Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.co Diphenhydramine (also known as DPH, Dimedrol, Benadryl, and many others) is a deliriant substance of the ethanolamine class. Diphenhydramine is a first-generation H1 antihistamine that is widely used as a generic, over-the-counter medication to treat allergies. When exceeding approved doses, diphenhydramine produces powerful deliriant effects Children 4 to 6 years of age—3.5 mg every four hours or 7.5 mg every six to eight hours, as needed. Children and infants up to 4 years of age—Use is not recommended . For extended-release oral suspension dosage form : For cough: Adults and children 12 years of age and older—60 mg every twelve hours, as needed
Description. Guaifenesin is an expectorant used to relieve chest congestion. In vivo. Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg. Guaifenesin or guaiphenesin, also glyceryl guaiacolate,is an expectorant drugsold over the counter and usually taken orally to assist the bringing up (expectoration) of phlegm from the airways in acute respiratory tract infectiion
Guaifenesin,physical properties,suppliers,CAS,MSDS,structure,Molecular Formula, Molecular Weight ,Solubility,boiling point, melting poin Guaifenesin: Taking the guaifensin should be ok. The question is, are you taking anything for your gastroesophageal reflux which could be causing your cough? 0. 0 comment. 1. 1 thank. Send thanks to the doctor. A 45-year-old female asked: what is a good mucolytic/expectorant drug? immediate-release 400mg guaifenesin doesn't help that much, even. Mucinex (Guaifenesin) Information Mucinex (guaifenesin) is classified as an expectorant and mucolytic, used to thin and loosen mucus secretions as well as relieve chest congestion. Less viscous mucus secretions helps to increase the efficiency of our mucociliary clearance mechanism , changing a dry, unproductive cough to a more productive one Active Ingredients: Guaifenesin 100 mg, Dextromethorphan Hydrobromide 10 mg. Guaifenesin is an expectorant that loosens mucus congestion in the throat and chest, making it easier to cough to clear the airways. Dextromethorphan is a cough suppressant that helps reduce the coughing reflex Veterinarian. DVM. 52,013 satisfied customers. my 7 month old papillon just ingested a 1/4 tablet of Mucinex. my 7 month old papillon just ingested a 1/4 tablet of Mucinex. Normal adult dose (2) tablets has 200mg guaifenesin. She was approx. 9 lbs. Do I read more
Lethal doses of zolpidem are dependent on several factors, such as the person's body weight, their tolerance level to the drug, their gender, and the use of any other drugs in conjunction with Ambien. Taking amounts of the drug greater than 150 mg of zolpidem per kilogram of an individual's body weight is most likely going to be fatal Guaifenesin Oral Solution Back to Top. H. HydrALAZINE Hydrochloride Injection, USP Hydrocodone Bitartrate and Homatropine Methylbromide Oral Solution, CII Hydrocortisone and Acetic Acid Otic Solution, USP Hydromorphone Hydrochloride Injection, USP CII (High Potency Formulation).
Guaifenesin. Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth. Guaifenesin is used to reduce chest congestion caused by the common cold, infections, or allergies. Guaifenesin may also be used for purposes not listed in this medication guide. Certificate of Analysi Guaifenesin is an expectorant that alleviates symptoms of mucus accumulation. Guaifenesin inhibits mucin production, increases mucociliary transport, and decreases the viscoelasticity of mucus in airway epithelial cells. G8101 MSDS PDF. Info Sheet: G8101 Info Sheet PDF. References
Chemsrc provides Guaifenesin / Dextromethorphan(CAS#:956596-18-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Guaifenesin / Dextromethorphan are included as well Download MSDS. Download COA. HPTLC-Densitometric Method for Determination of Ascorbic Acid, Paracetamol and Guaifenesin in Presence of Their Toxic Impurities Nada S Abdelwahab, Eglal A Abdelaleem, Maha M Abdelrahman Journal of Chromatographic Science, Volume 57, Issue 2, February 2019, Pages 149-155. Guaifenesin with codeine cough syrup; Other medicines may also contain codeine. Codeine Overdose Treatment. A codeine overdose is a medical emergency. If you suspect a loved one is overdosing on codeine, you should immediately give the opioid reversal agent naloxone (Narcan) if it is available and call 911. If the person is overdosing on a. Guaifenesin. Catalog No. T0739 CAS 93-14-1. Synonyms: Glycerol guaiacolate, Guaiphenesin, Guaiacol glyceryl ether. Purity 99.69% Datasheet MSDS. Guaifenesin is an expectorant that also has some muscle relaxing action. It is used in many cough preparations. Guaifenesin, CAS 93-14-1. Pack Size. Availability